Technologies
Innocoll's products are based upon its biocompatible, biodegradable and fully resorbable localized drug delivery technologies trademarked as CollaRx® and LiquiColl®. These are matrix constructs of Type-1 collagen which can be prepared in the form of a lyophilized CollaRx sponge, a film-cast CollaRx membrane, or an aqueous-based collagen dispersion/gel (LiquiColl).
Localized delivery provides a way of targeting the optimum concentration of a drug to precisely where it is needed, rather than distributing excessive and sometimes unnecessary doses throughout the body via systemic circulation. Such delivery systems can often lead to more effective and safer products than those administered intravenously or orally, particularly with respect to unwanted side effects. A wide variety of drugs are known to act locally; including antibacterials, anesthetics, analgesics, anti-inflammatories, anti-cancers, wound healing agents, and various growth factors and modulators, which provide great opportunity for the CollaRx and LiquiColl technologies.
Technology Benefits
The benefits offered by Innocoll's CollaRx and LiquiColl technologies over other locally-acting drug matrices and advanced wound care products are as follows:
- Fully biocompatible and biodegradable with a long history of safe and effective use.
- Can be applied to a topical wound, surgically implanted, or (in the case of LiquiColl)injected into a subcutaneous tissue defect or joint.
- Suitable for a wide range of active ingredients (hydrophilic, lipophilic and macromolecules), including combinations thereof.
- Versatile drug loading capability from micrograms to grams of single or multiple active ingredients.
- Rate of drug release can be controlled by formulation and process variations.
- Ready-to-use formats for ease of administration - no need for any mixing in the operating theatre.
- Products can be implanted using laparoscopy and are easily manipulated according to the site of application.
- Drug delivery matrices provide hemostatic and wound healing benefits.